From Emmy Award-winning executive producer, creator and director Glenn Gordon Caron ("Moonlighting") comes "Medium," a chilling drama series inspired by the real-life story of research medium Allison DuBois. Emmy winner Patricia Arquette ("Stigmata," "Flirting with Disaster") stars as a young wife and mother who, since childhood, has been struggling to make sense of her dreams and visions of dead people. Arquette received the Emmy in the Outstanding Lead Actress in a Drama Series category after the telecast of the initial 16 episodes of the critically acclaimed series, and has received several subsequent Emmy, Golden Globe and SAG nominations for this role.

Patricia's sister, Rosanna Arquette will be guest starring in the upcoming episode "Lady Killer" in the highly acclaimed "Medium" (April 7th). EZ chatted with the sisters on just about everything! One of the best things, was that the two of them did more talking to each other than anyone else! They almost interviewed 'each other'!!! Great family, great actors... GREAT INTERVIEW! Enjoy!

Interviewer:       I think that’s really interesting the way that birth order affects, you know, relationships and so forth . And so I wanted to ask you both of that because, Rosanna, like, you were eight years old when Patricia was born and 11 when David was born . And that’s got to be a different kind of a sibling relationship than others. What do you remember of your relationship with the kids when, like, you were a teenager and they were still preschool? And then I want to ask Rosanna – Patricia the same thing, but, first of all, Rosanna.

Rosanna Arquette:    Well, yeah, I kind of babysat a lot and, you know, I left kind of, I left home early so I missed a lot of some of their years and would come back on holidays and stuff . But it seems like as we got older we became closer than when we were younger, you know,

Interviewer:        So you’re saying that this is really – you just knew them as a bunch of a little kids then and you knew them as real people much later on or?

Rosanna Arquette:    Yes. I mean, they were my babies, you know, they were little kids and later, you know, they grew up to be fine, talented adults .

Interviewer:        And Patricia the same thing; kind of how did you think of Rosanna when you were little and then just kind of how did that evolve?

Patricia Arquette: Well I think Rosanna did fall into that sort of trap of having to help with so many siblings because there was four of us. And so she definitely had to help my mom out; my dad was on the road when were little a lot and trying to make a living; he was in a band at the time . And I do remember Rosanna cleaning my ears and saying…

Rosanna Arquette:    Talking about the cleaning your ear thing.

Patricia Arquette: …oh there’s some sweet potatoes in there . And I remember her teaching me dances; really cute little dances to Mr . Big Stuff and…

Rosanna Arquette:    Bumping – The Bump . Did I teach you The Bump?

Patricia Arquette: Uh huh, The Bump and we would listen to her records, like, Jackson Five . And she, you know, she was my big sister; she’s always been my big sister and taught me a lot of stuff about the world.

Rosanna Arquette:    Oh, I remember Patricia came to the set of, was it – when did you come and you stayed with me in New York ? I guess I was doing…

Patricia Arquette: You were – Desperately Seeking Susan.

Rosanna Arquette:    I was doing Desperately Seeking Susan and you had a punk haircut like shaved head on one side and black…

Patricia Arquette: Yeah.

Rosanna Arquette:    …Patricia said she wanted to be an actress and I thought that was so exciting, she was going to be an actress.

Interviewer:        Patricia; can you kind of recall when it was that all of a sudden you thought, “Hey, I’ve got a really cool older sister?”

Patricia Arquette: I kind of always thought my sister was really cool, as a matter of fact . I’d get her old makeup and I got the best hand me downs, you wouldn’t believe it; unbelievable hand me downs . It was really cool.

Rosanna Arquette:    Now I get hand me downs .

Interviewer:        I was just wondering how does it feel to finally be working together? And why did it take so long?

Rosanna Arquette:    You can answer that, Patricia.

Patricia Arquette: Okay . This is Patricia . You know, we did work together before one time; it was on a documentary, "Searching for Debra Winger."

Rosanna Arquette:    Oh, yeah.

Patricia Arquette: But that was not – that was a documentary, it wasn’t fiction . So this has been our first fictitious experience so to speak. I don’t know why it’s taken so long because we’ve always wanted to.

Rosanna Arquette:    I know her – hi, it’s Rosanna . Her – Glenn, the creator, said he was just waiting for the right one – the right show; there was just never one that he thought was the right one . And then this one was written for a man and they decided to turn it into a woman . And so here it happened. But, I have to say Patricia’s the hardest working girl in show business . No one knows how hard that show really is because they don’t have a full on script every day so it’s pages and pages of dialogue that the actors have to memorize…which was really challenging for me since, you know, my show got canceled a year ago so I did not have that muscle memory and I was just like, “Oh my god . ” It was intense . And she works very hard – those guys and David and – her co-star, all of them.

Patricia Arquette: It was hard for me in that I was smiling so much at what Rosanna was doing and she’s cracking me up . So it was really enjoyable . It was really…

Rosanna Arquette:    I don’t know if it was supposed to be comedic but…

Patricia Arquette: It was . It was really good.

Rosanna Arquette:    I kept finding all this stuff and it made laugh - but, maybe . He has a sense of humor, Glenn…

Patricia Arquette: Yeah.

Rosanna Arquette:    …you know.

Patricia Arquette: Think about Moonlighting.

Rosanna Arquette:    Yeah, that’s what it had, yeah, so it had that little element . But it’s definitely, you know, she works – you do a great job, Patricia, I don’t know . It’s – the people don’t know – the people that are watching that it seems very simple but it’s hard .  

Interviewer:        This is for Patricia . Now that the two of you have worked on the show together are there any plans to get David on in the future?

Patricia Arquette: I don’t know; I would love that . David’s directed two episodes. Rich – our brother Rich has been on – I’m not sure if it was the second year, I think it was the second year . He played one of our killers . And I would love Alexis to come on and David to come on . But, you know, David has directed two of them and I don’t know how many favors he owes me at this point .

Interviewer:        So real quick I’m just wondering: how was the experience? How different were your acting styles, I’m wondering? And, Rosanna, just give us a little bit more of a sense of your character.

Rosanna Arquette:    I was discovering the character as I went along because I just knew that I was given these pages because they worked that – the way that Glenn works he kind of has a script, you have an idea and then new pages come . And so I was figuring her out as we were going. But she, you know, started off as this woman who was a – who’s the cougar women who lures young men in and kills them, which was kind of interesting to do; I’d never played anybody like that so that was fun. And I was impressed with how they work and how Patricia’s, you know, her crew loves her so much and it’s a really challenging hard work because she has so much dialogue and…

Patricia Arquette: Poor Rosanna, her first day on the job it was like a love scene.

Rosanna Arquette:    Two days in a row of love scenes.

Patricia Arquette: I kept saying, “Am I going to work with my sister?”

Rosanna Arquette:    I thought she was playing a joke on me.

Patricia Arquette: Because there – because we kept saying, “What’s the ending?” And he kept saying, “I don’t know yet . I’m not sure yet.”

Rosanna Arquette:    Oh, that was funny.

Interviewer:        How much interaction do the two of you actually have in the episode? Because the way a lot of them works is Allison doesn’t often see, you know, interact with the person she’s chasing until the very end of the episode.

Rosanna Arquette:    Yeah.

Patricia Arquette: Yeah we have a little bit . We have some a . . .

Rosanna Arquette:    It’s like interrogation, two interrogations - or, you know, scenes like that.

Patricia Arquette: Rosanna’s my dream girl a lot – dreaming about her a lot.

Rosanna Arquette:    I come in her dreams.

Interviewer:        Rosanna, this isn’t the question but it was very funny, my uncle gave you one of your very earliest roles back when you just started . He hired you for the – he directed your episode of Eight is Enough where…

Rosanna Arquette:    Oh, you’re kidding?

Interviewer:        … and girlfriend.

Rosanna Arquette:    Oh, wow.

Interviewer:        I throw that out there.

Rosanna Arquette:    What’s his name? What’s his name? Sorry, my brain…

Interviewer:        Gerald Mayer.

Rosanna Arquette:    Oh, okay . Cool . Tell him, “Hi.”

Interviewer:        I – well, you kind of answered a little bit as far as acting together in the future and all that and David working with you guys . Do you keep a close-knit family now, reunions, holidays and stuff?

Patricia Arquette: Oh, yeah, we do . We spend all our holidays together and…

Rosanna Arquette:    Easter . We’re there this Sunday . Patricia’s – does her big Easter time.

Patricia Arquette: Yeah.

Interviewer:        And I hear your daughter just loves Alexis.

Patricia Arquette: Oh, yeah.

Rosanna Arquette:    All of our girls love Alexis . All the girls want to be like Aunt Alexis.

Patricia Arquette: They do, they ask fashion advice.

Interviewer:        Oh, that’s so cute . And are they ever going to give poor Joe a job on the show?

Rosanna Arquette:    Oh.

Patricia Arquette: Yeah, I know, I’m going to send him to Debtors Anonymous if he keeps not working.

Rosanna Arquette:    Man, well I like the house husband – I love someone that just can take care of everything at home and while you go to work.

Patricia Arquette: Yeah, it’s nice.

Rosanna Arquette:    Sounds good to me.

Patricia Arquette: It is nice . We do have to have some scenes of him cooking dinner.

Rosanna Arquette:    Yeah.

Patricia Arquette: That would be good . Doing the laundry; bring it on.

Rosanna Arquette:    Yeah.

Interviewer:        Yeah, we haven’t seen him do laundry yet.

Patricia Arquette: No, I’ve got to tell those guys that . You know, it’s kind of neat, when we have our kids on the set, you know, Bridgette, Maria Lark, all the girls that are on the show, she came in and she’s got four teeth that she’s wiggling and wiggling them . So I ran upstairs to Glen and I said, “You know, she’s got loose teeth . You’ve got to write it in.”

Rosanna Arquette:    Yeah.

Patricia Arquette: And the next morning we had a loose teeth scene…

Interviewer:        Oh.

Patricia Arquette: I love Bridgette.

Interviewer:        Yeah, definitely; get more Bridgette on, she is just the best . She is just the cutest thing.

Patricia Arquette: Yeah, she’s so funny.

Interviewer:        Rosanna, I’m just wondering when you were young, maybe even now; who was better at pulling the other’s hair?

Rosanna Arquette:    Alexis.

Interviewer:        Who pulled it stronger?

Rosanna Arquette:    I don’t think there was any of that stuff because, you know, I’m much older and so it was more of like braiding hair.

Interviewer:        Yeah, okay, okay . And also I’m just wondering if there – given the fact that it’s Medium and so much is about the minds here, I’m wondering if there’s a mind meld between sisters when they both appear on the same episode? If there’s a shortcut the two of you can take that nobody else could?

Rosanna Arquette:    What do you think, (Tish)?

Patricia Arquette: Well I think I was – I was really enjoying Rosanna’s work . And I kind of had to keep catching myself because my own self was coming through . Does that – I don’t think Allison is quite as on board . So I had to keep kind of putting myself in check. It was so fun to watch her so in that way it was really fun being at work and fun to be around her . But I enjoy her so much it was sort of like weird to try to keep pulling myself back from that.

Rosanna Arquette:    Oh, that’s so funny .

Interviewer:        …in some interviews the two of you described as your growing up in the family as chaos; but you also describe your parents as great explorers . I’m wondering if the two of you have picked up the mantle of your parents and serving as explorers and how that manifests itself? Rosanna?

Rosanna Arquette:    I did lots of exploring in the years – in my life that I – and I’d love to do some more . It’s constantly – a lot of self-exploration; I’m surrounded by a lot of self-exploration book right now. But I know, Patricia, you just went to Egypt . That’s like, you know, she’s always out and finding great things to do and traveling in the world . And…

Patricia Arquette: Yeah, I was just in Egypt and India . That was amazing . But I do think our parents, their main voyages were – my mom was born Jewish and supposed to go to school to marry a Jewish man . And then she ended up marrying a man who had been raised Christian . And then he converted to Islam, so…their exploration was, you know, about different religions, comparative religions. So when I saw this warfare going on between these different religions I really didn’t understand it because in our house we could do little Hanukah things or we would fast for Ramadan . So I didn’t see where the warfare came in…

Rosanna Arquette:    They’re so similar, both religions anyway, that’s the thing.

Interviewer:        Yeah, yeah . One last question, Patricia, you’ve been quoted as saying, “Every time one of my siblings comes on set the crew realizes that I have yet another sibling nicer than me . ” This…

Rosanna Arquette:    No.

Interviewer:        …did this streak continue?

Patricia Arquette: Yeah, it struck again . It struck again.

Rosanna Arquette:    Maybe not the first day; the first day I was just a little off because I, you know, or this figuring it all out, so . But hopefully by the end, you know.

Patricia Arquette: Oh, by the end it happened . The day that was done, the next day everybody was like, “Can’t we get that Arquette back? Why do we have this one again? Can’t we switch back to the other one?”

Rosanna Arquette:    I really like David, too, he’s great, the guy who plays Scanlon.

Patricia Arquette: Yeah, he’s so great .

Rosanna Arquette:    Wonderful actor; great sense of humor, sexy and gorgeous .

Interviewer:        I had a question for Rosanna: I was wondering how you enjoy playing a villain?

Rosanna Arquette:    You know, it was challenging . There was this one moment where I had to strangle this man . And I found myself getting really nauseous, like, every time I would do I kind of felt sick to my stomach . And I said, this is, this feeling - because - that comes – it’s because that is wrong, you know . I mean, it’s amazing the people who actually really do these things, how they can get to that place. But it was hard . It was – I don’t know if I would want to do it a lot . It was interesting to be in somebody’s skin that could do that . But it was, yeah . I don’t know . It was interesting to play, for me, something that I’ve never done before because I haven’t ever done that, so.

Interviewer:        And was it difficult for you, Patricia, to deal with – particularly because she’s your sister, to react to her as though she’s a bad guy? I don’t know how much…

Patricia Arquette: Yeah, I would find myself smiling really big . And then I’d have, oh, no, it’s not supposed to be funny . Oh, stop, what are you doing? No, you’re supposed to be looking at her surly . Hmmm, you’re not sure if she’s telling the truth, you know . I was having this inner war with myself because – and then she had this one line, which was just – every time she would say it…

Rosanna Arquette:    Oh my god.

Patricia Arquette: …she’d say, “A middle aged mouse burger.”

Rosanna Arquette:    We were going, “Middle aged mouse burger . ” And I – we’d go, “Excuse me, what’s a mouse burger?”

Patricia Arquette: Every time she’d say “Mouse burger,” I would crack up.

Rosanna Arquette:    We ended up having to cut it, right?

Patricia Arquette: Yeah, we ended up cutting it because…

Rosanna Arquette:    No on knew what – do you know what a mouse burger is?

Interviewer:        I spoke to you a few years ago after Hurricane Katrina for Below the Line . I don’t know if you…

Patricia Arquette: Yeah .  

Interviewer:        You did such a great effort with (Jake Webber) and your crew getting supplies to the Katrina victims and really spearheading that . And I just wanted to know if there was any kind of an update or if you had any – if your crew was still involved in helping or if you’d stayed in touch with any of the people in Louisiana that you met and helped?

Patricia Arquette: You know, I haven’t . I’ve talked to some people that are still working out there . Different – it’s so political even when it’s not in politics. You know, some times people start doing things, you’re like, “I’m not sure that’s the road I want to go down . ” Or, “I’m not sure that’s the most effective route . ” I mean, I think it’s a horrific tragedy that that area is still as decimated as it is. And our country is just basically turned its back on it . There are different programs that I do believe in there but pretty much most of the people that were working on the project we worked on, disbanded and some people moved off to do other things . But, you know, at a certain point you kind of have to think strategically like, “All right, what do I think this needs now?” If that makes sense…

Interviewer:        Your crew, though, is so awesome; are you still really close with your crew on Medium?

Patricia Arquette: Oh, we’re so close; they’re so sweet . I love my crew so much; they really have my back.

Rosanna Arquette:    They love her.

Patricia Arquette: Yeah, they do . Or I hit them.

Interviewer:        And, Rosanna, I know you talked a little bit about what it was like to play a villain in this particular episode, but what about playing a cougar of sorts; was that a role that you were comfortable in? And, Patricia, how did you feel about your sister being a cougar?

Rosanna Arquette:    Yeah, it was, I mean, it was fun . I was discovering the character as I went along . And so – and, which was kind of a really interesting way to working and they do that a lot on that show . So, you know, I’ve never been one to, you know, go out really with younger men but, you know, it did spark and idea in me . Like, wow, this is not so bad.

Interviewer:        And, Patricia, what did you think of the character?

Patricia Arquette: I thought, you know, because I know my sister so well it’s a testament to what a great actress she is . I mean, physically she is a very beautiful woman but she’s a very natural woman in real life . So it’s – I knew she would look gorgeous and she looks gorgeous . But to see her as this sort of carnivorous mercenary kind of dangerous person was so different for me to see her in that. So part of the reason I was just enjoying it so much was enjoying my sister’s incredible talent.

Rosanna Arquette:    Aww .

Interviewer:        How long was this in the actual planning stages? I mean you were just talking about wanting to do it back then but . . . we were just waiting for…

Rosanna Arquette:    Oh, do – wanting to do a guest on the show?

Interviewer:        Yeah.

Rosanna Arquette:    I don’t know, I mean the shows been on – this is her fourth season, right? And then I guess Glenn finally found the right story to tell . And – says, you know, would I do it? And I was, yeah, great.